Publications

Aging is associated with the impairment of stem cell activation, leading to the functional decline of tissues and increasing the risk for age-associated diseases. The old, damaged or unrepaired tissues disturb distant tissue homeostasis by secreting factors into the circulation, which may not only serve as biomarkers for specific age-associated pathologies but also induce a variety of degenerative […]

Melod Mehdipour, Jessy Etienne, Chao Liu, Taha Mehdipour, Cameron Kato, Michael Conboy, Irina Conboy, Dobri D. Kiprov, Attenuation of age-elevated blood factors by repositioning plasmapheresis: A novel perspective and approach, Transfusion and Apheresis Science , Volume 60, Issue 3, 2021, https://doi.org/10.1016/j.transci.2021.103162.

Aging is a gradual biological process characterized by a decrease in cellular and organism functions. Aging-related processes involve changes in the expression and activity of several proteins. Here, we identified the transmembrane protease serine 11a (TMPRSS11a) as a new age-specific protein that plays an important role in skin wound healing. TMPRSS11a levels increased with age […]

Fernandez, C, Burgos, A, Morales, D, et al. TMPRSS11a is a novel age-altered, tissue specific regulator of migration and wound healing. The FASEB Journal. 2021; 35:e21597. https://doi.org/10.1096/fj.202002253RRR

Flow cytometry (FCM) is an analytic technique that is capable of detecting and recording the emission of fluorescence and light scattering of cells or particles (that are collectively called “events”) in a population1. A typical FCM experiment can produce a large array of data making the analysis computationally intensive2. Current FCM data analysis platforms (FlowJo3, […]

Wong, N., Kim, D., Robinson, Z. et al. K-means quantization for a web-based open-source flow cytometry analysis platform. Sci Rep 11, 6735 (2021). https://doi.org/10.1038/s41598-021-86015-6

As the fields of aging and neurological disease expand to liquid biopsies, there is a need to identify informative biomarkers for the diagnosis of neurodegeneration and other age-related disorders such as cancers. A means of high-throughput screening of biomolecules relevant to aging can facilitate this discovery in complex biofluids, such as blood. Exosomes, the smallest […]

DeCastro J, Littig J, Chou PP, Mack-Onyeike J, Srinivasan A, Conboy MJ, Conboy IM, Aran K. The Microfluidic Toolbox for Analyzing Exosome Biomarkers of Aging. Molecules. 2021; 26(3):535. https://doi.org/10.3390/molecules26030535

Our recent study has established that young blood factors are not causal, nor necessary, for the systemic rejuvenation of mammalian tissues. Instead, a procedure referred to as neutral blood exchange (NBE) that resets signaling milieu to a pro-regenerative state through dilution of old plasma, enhanced the health and repair of the muscle and liver, and […]

Many patients with COVID-19 experience a range of debilitating symptoms months after being infected, a syndrome termed long-haul COVID. A 68-year-old male presented with lung opacity, fatigue, physical and cognitive weaknesses, loss of smell and lymphocytopenia. After rounds of therapeutic plasma exchange (TPE), the patient returned to normal activities and work. Mechanistically in the patient’s […]

Skeletal muscle is among the most age-sensitive tissues in mammal organisms. Significant changes in its resident stem cells (i.e., satellite cells, SCs), differentiated cells (i.e., myofibers), and extracellular matrix cause a decline in tissue homeostasis, function, and regenerative capacity. Based on the conservation of aging across tissues and taking advantage of the relatively well-characterization of […]

Flow cytometry (FCM) is an analytic technique that is capable of detecting and recording the emission of fluorescence and light scattering of cells or particles (that are collectively called “events”) in a population. A typical FCM experiment can produce a large array of data making the analysis computationally intensive. Current FCM data analysis platforms, while […]

Heterochronic blood sharing rejuvenates old tissues, and most of the studies on how this works focus on young plasma, its fractions, and a few youthful systemic candidates. However, it was not formally established that young blood is necessary for this multi-tissue rejuvenation. Here, using our recently developed small animal blood exchange process, we replaced half […]

Heterochronic blood sharing rejuvenates old tissues, and most of the studies on how this works focus on young plasma, its fractions, and a few youthful systemic candidates. However, it was not formally established that young blood is necessary for this multi-tissue rejuvenation. Here, using our recently developed small animal blood exchange process, we replaced half […]