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The Conboy Laboratory

Engineering Longevity

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Research

Time and entropy are not the sole decisive factors in aging.

The interconnected research venues pursued in the lab help to understand how the process of tissue repair is controlled, why the injured tissues are not productively repaired as we age; and to establish approaches that restore the regenerative potential both to the aged organ stem cells and transplanted cells exposed to the aged organ environments.

We focus on broad rejuvenation of tissue maintenance and repair, stem cell niche engineering, directed organogenesis, and making CRISPR a therapeutic reality.

We typically assay all three germ layer tissues, e.g. brain, muscle and liver.

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Discoveries & Areas of Focus

  • Establishing New Aging & Rejuvenation Paradigms
  • Defined Pharmacology for Tissue Repair
  • Making Gene Editing A Therapeutic Reality
  • Heterochronic Parabiosis and Beyond
  • Mammalian In Vivo Bio-Orthogonal Proteomics
  • Understanding Fundamental Properties of Embryonic Stem Cells 
  • Understanding Fundamental Properties of Adult Stem Cells
  • Publications 2020 and beyond
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